If you’re desperate, call a professional exterminator. They’ll spray a barrier around your home that lasts months. But know this: chemical sprays kill good bugs too, and some can be harsh for pets or kids. Use them only for serious infestations.
A better “nuclear” option? Get a cat. Cats are natural spider hunters. Mine once brought me a half-eaten daddy longlegs as a gift. It was gross. I was proud.